It is also used to treat or prevent high uric acid levels that occur as a result of certain types of chemotherapy. Probenceid chemistry name. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Select one or more newsletters to continue. Version: 4.03. prednisone, allopurinol, triamcinolone, dexamethasone, betamethasone, Decadron, febuxostat, Uloric, Zyloprim, allopurinol / lesinurad. Medscape - Gout dosing for colchicine/probenecid, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Your doctor may prescribe an additional medicine called colchicine. 43 Peak concentrations are reached in 1 to 5 hours, and the peak action occurs about 2 hours after an oral dose with effects lasting up to 8 hours. Probenecid will help prevent gout attacks but it will not relieve an attack that has already started. Do not take two doses at one time. Not all possible drug interactions are listed here. Copyright 1996-2021 Cerner Multum, Inc. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. If you need surgery, tell your surgeon you currently take probenecid. 1-888-INFO-FDA (1-888-463-6332) Contact FDA Review side effects, dosage, warnings and precautions, and drug interactions prior to taking this medication. Used in the treatment of gout. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. It depends on the child's weight, as well as on the condition being treated. Overdose symptoms may include nausea, vomiting, or stomach discomfort. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Affected cytochrome P450 isoenzymes and drug transporters: OAT1 and OAT3 Probenecid inhibits the drug transporters OAT1 and OAT3. If you miss a dose of probenecid, take it as soon as possible. 43 Probenecid is extensively protein bound, ranging from 83% to 95% depending on the dose. Tap card to see definition . Probenecid is soluble in dilute alkali, in alcohol, in chloroform, and in acetone; it is practically insoluble in water and in dilute acids. It acts on the kidneys to help the body eliminate uric acid. For probenecid, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to probenecid or any other medicines. Probenecid may cause false test results with copper sulfate urine sugar tests (Clinitest®), but not with glucose enzymatic urine sugar tests (Clinistix®). Probenecid systemic 500 mg (MYLAN 156 500), We comply with the HONcode standard for trustworthy health information -. The results of some tests may be affected by probenecid. If this does not work, an antacid may be taken. Tell your doctor about all your other medicines, especially: an NSAID (nonsteroidal anti-inflammatory drug) such as indomethacin, ketoprofen, meclofenamate, or naproxen (Aleve). Children: It is not likely that probenecid will be needed to treat gout or to remove uric acid from the body in children. You may be given other medications to also help prevent kidney stones. Using alcohol or tobacco with certain medicines may also cause interactions to occur. To help prevent this, your doctor may want you to drink at least 10 to 12 full glasses (8 ounces each) of fluids each day, or to take another medicine to make your urine less acid. NCI Thesaurus (NCIt) Probenecid is a uricosuric agent used for the treatment of gout usually in combination with other agents. Available for Android and iOS devices. SW Probenecid(probenecid): ... Drug Interactions . Used in the treatment of gout., Probenecid has been used in patients with some renal impairment, but dosage requirements may be increased; probenecid may not be effective in chronic renal insufficiency particularly when the glomerular filtration rate is ≤30 mL/minute because of its mechanism of action, probenecid is not recommended in conjunction with penicillin in the presence of known renal impairment For non-prescription products, read the label or package ingredients carefully. Generic Name: probenecid (proe-BEN-e-sid). Many medicines have not been studied specifically in older people. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. sulfonamide derrivitive. You may report side effects to the FDA at 1-800-FDA-1088. Medically reviewed by Drugs.com on Dec 9, 2020. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Probenecid is also used to increase the blood levels of penicillin-type antibiotics used for the treatment of gonorrhea. Probenecid Oral tablet drug summary. Probenecid is used to treat chronic gout and gouty arthritis. Probenecid is used in the treatment of chronic gout or gouty arthritis. Probenceid chemistry name. Probenecid does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks. It is best to drink a full glass of water with each dose and at least another 8 glasses (8 ounces each) a day while taking this drug in order to prevent kidney stones. Uricosric antigout agent. Probenecid is also used to make certain antibiotics more effective by preventing the body from passing them in the urine. Probenecid is used in the treatment of chronic gout or gouty arthritis. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Drug class: Xanthine Oxidase Inhibitors Allopurinol (Zyloprim) is a moderately priced drug used to treat the symptoms of gout . Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. The effect of concurrent probenecid administration on the pharmacokinetics of cephalosporin antibiotics varies with the available cephalosporins. Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. For patients taking probenecid for gout or to help remove uric acid from the body: The dose of probenecid will be different for different patients. Follow your doctor's orders or the directions on the label. After this, the dose will depend on the amount of uric acid in your blood or urine. Probenecid: Belongs to the class of preparations increasing uric acid excretion. Older children and teenagers may need the same amount as adults. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Your doctor may also instruct you on how to decreas… You may report side effects to FDA at 1-800-FDA-1088. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Your doctor may also instruct you on how to decrease acidity in your urine (e.g., avoid large amounts of ascorbic acid/vitamin C) to pr… The following information includes only the average doses of probenecid. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. However, if you take probenecid regularly as directed by your doctor, the attacks will gradually become less frequent and less painful than before. This will depend on the dose of aspirin or other salicylate that you take, and on how often you take it. Probenecid is sometimes used with certain kinds of antibiotics to make them more effective in the treatment of infections. Probenecid colchicine (probenecid / colchicine) can be used to stop gout attacks but you shouldn't start it until after the gout attack is over. You should not use this medicine if you have uric acid kidney stones, a gout attack that has already started, or a blood cell disorder. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. It is primarily used in treating gout and hyperuricemia. 10903 New Hampshire Avenue Silver Spring, MD 20993 Ph. Do not double doses. Visit cvs.com for more details. Medically reviewed by Drugs.com. Children: The dose will have to be determined by the doctor. Call your doctor for medical advice about side effects. probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine. It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. [56579] Probenecid inhibits the tubular secretion of penicillin and usually increases penicillin plasma levels by any route the antibiotic is given. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. It is also used to increase the effectiveness of some antibiotics. Using probenecid with any of the following medicines is not recommended. It is important that you follow your doctor's instructions very carefully. We comply with the HONcode standard for trustworthy health information -, Cancer being treated by antineoplastics (cancer medicine) or radiation (x-rays) or, Kidney disease or stones (or history of) or, Stomach ulcer (history of)—The chance of side effects may be increased. If a child needs probenecid, however, the dose would have to be determined by the doctor. Drug class(es): aminopenicillins. Probenecid is a uricosuric and renal tubular blocking agent and is used in combination … Most people need 2, 3, or 4 tablets a day, but some people may need higher doses. The amount of medicine that you take depends on the strength of the medicine. Click card to see definition . It has the following structural formula: Probenecid, USP is a white or nearly white, fine, crystalline powder. probenecid may affect your body's response to anesthesia. probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Studies on the effects of probenecid in patients with gout have been done only in adults. Before you have any medical tests, tell the person in charge that you are taking probenecid. Store at room temperature away from moisture, heat, and light. Use the medicine exactly as directed. Call your doctor for medical advice about side effects. Other drugs may affect probenecid, including prescription and over-the-counter medicines, vitamins, and herbal products. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Available for Android and iOS devices. Probenecid is a uricosuric and renal tubular transport blocking agent. After you have been taking probenecid for several months, they may stop completely. To prevent gout, take this medication by mouth, usually twice daily with food or antacids to reduce stomach upset or as directed by your doctor. Along with its needed effects, a medicine may cause some unwanted effects. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The presence of other medical problems may affect the use of probenecid. Probenecid will help prevent gout attacks only as long as you continue to take it. Probenecid should not be given to a child younger than 2 years old. Call your doctor if you have worsening gout symptoms. These medications are not usually taken together. Probenecid is used to treat gout and gouty arthritis. When you are taking probenecid, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. nausea, vomiting, stomach pain or swelling; puffy eyes, swelling in your ankles or feet, weight gain; or. puffiness or swellings of the eyelids or around the eyes, shortness of breath, troubled breathing, tightness in chest, or wheezing, changes in the skin color of the face occurring together with any of the other side effects listed here, or skin rash, hives, or itching occurring together with any of the other side effects listed here, lower back or side pain (especially if severe or sharp), skin rash, hives, or itching (occurring without other signs of an allergic reaction), sores, ulcers, or white spots on lips or in mouth, sore throat and fever with or without chills, swelling of face, fingers, feet, and/or lower legs, flushing or redness of face (occurring without any signs of an allergic reaction). Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Even if you take another medicine for gout attacks, continue to take probenecid also. colchicine/probenecid systemic. Therapeutic class: Antigout drug, tubular blocking agent. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Do not keep outdated medicine or medicine no longer needed. Uses of Probenecid-hyperurrcemia in gout-gouty arthritis
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