; Dominguez, J.; Cantu, T.; Brittain, W.; Irvin, J.; Betancourt, T. Biodegradable DNA-enabled poly(ethylene glycol) hydrogels prepared by copper-free click chemistry. ; Lee, D.S. Google Patents US20130018110A1, 17 January 2013. ; McLemore, R.Y. In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery. Both chemical and physical approaches are used to enhance the transdermal permeation of actives [, Microneedle arrays fabricated from cross-linked hydrogel polymers upon insertion into the skin can absorb interstitial fluid to form continuous channels connecting to dermal circulation. The biocatalytic transformations of glucose oxidase included within the pH-responsive DNA containing hydrogels provides a glucose-triggered matrix for the controlled release of insulin and therefore behaves as an artificial pancreas [, The responsiveness towards ionic strength is typically observed in polymers with ionizable groups such as polyelectrolytes. ; Mohamed, A.M.; Pottathil, S.; Sabna, K.; Mithra, C.; Abu, T. Advances of Non-iron Metal Nanoparticles in Biomedicine. Goodall, S.; Jones, M.L. ; Mikhalovsky, S.V. ; Hurler, J.; Ferderber, K.; Golja GaÅ¡paroviÄ, P.; Å kalko-Basnet, N.; FilipoviÄ-GrÄiÄ, J. Surface-specific modification/grafting on polymer structures can modulate the drug flux by changing the permeability in response to external stimuli and therefore release kinetics. Abruzzo, A.; Bigucci, F.; Cerchiara, T.; Saladini, B.; Gallucci, M.C. Zheng, H.; Yoshitomi, T.; Yoshimoto, K. Analysis of Chirality Effects on Stem Cell Fate Using Three-dimensional Fibrous Peptide Hydrogels. Smart Hydrogels in Tissue Engineering and Regenerative Medicine. Removal may be surgical, mechanical, chemical, autolytic (self-digestion), and by maggot therapy.. Kaur, G.; Adhikari, R.; Cass, P.; Bown, M.; Gunatillake, P. Electrically conductive polymers and composites for biomedical applications. ; writingâoriginal draft preparation, J.S., N.S., S.G. and P.S. Deng, Y.; Ren, J.; Chen, G.; Li, G.; Wu, X.; Wang, G.; Gu, G.; Li, J. Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration. ; Vatankhah, E.; Ramakrishna, S. Electrospun aligned PHBV/collagen nanofibers as substrates for nerve tissue engineering. ; Mooney, D.J. ; McCarthy, H.O. (a) Peptide-based hydrogels could be made antimicrobial through use of AMPs for gelation or incorporation of antimicrobial agents (NPs, metal ions, or antibiotics). Park, S.H. Hydrogels are well adapted to accommodate these drugs in their polymeric networks to protect them from the acidic conditions of the stomach. Overstreet, D.J. Hydrogels as a wound dressing match most of the desirable features expected for wound healing and are the most appropriate material for burn patients. Alvarez-Lorenzo, C.; Hiratani, H.; Gómez-Amoza, J.L. ; Luo, D. Enzyme-catalysed assembly of DNA hydrogel. To achieve this target, natural polymers with anionic pendant groups are grafted with acrylic acid derivatives to obtain stimuli-sensitive behavior in the final hydrogel polymer. An injectable hydrogel containing gold and laponite nanoparticles was tested to improve the clinical efficacy of cardiovascular regeneration [, A buccal drug delivery system has attracted keen attention since the buccal mucosal membrane is more permeable and allows rapid permeation of pharmaceutical actives into the systemic circulation. He has published over 100 original research articles, 11 reviews in peer reviewed journals, edited 2 books and filed 2 patent applications. Examples include delivery of biofilm dispersal agents to prevent infection and accelerate healing of contaminated bone wounds, and delivery of Wnt signaling inhibitors to enhance cutaneous wound healing. Ankareddi, I.; Brazel, C.S. ; Widiyanti, P.; Siswanto. An injectable, click-crosslinked, cytomodulin-modified hyaluronic acid hydrogel for cartilage tissue engineering. Insertion of traditional SCL pre-soaked in drug solutions or post application of eye drops have the ability to release drugs, decreasing elimination and sorption across conjunctiva. ; Ko, J.; Jang, M.H. ; Kim, S.I. Autolytic debridement is contraindicated for infected wounds. ; Alhaider, I.A. Perinelli, D.R. ... or hydroactive. Migdadi, E.M.; Courtenay, A.J. Permeability of moisture and gases through the film for wound dressing is essential to keep the wound comfortable and enhance the healing process. Lin, Q.; Xu, X.; Wang, B.; Shen, C.; Tang, J.; Han, Y.; Chen, H. Hydrated polysaccharide multilayer as an intraocular lens surface coating for biocompatibility improvements. Collagen is used either alone or in combination with added constituents to promote biological and/or mechanical characteristics of the scaffold. Molecularly imprinted polymers are extensively probed in hydrogel contact lenses for improving drug entrapment as well as prolonging their release duration. Fabrication of three-dimensional porous carbon scaffolds with tunable pore sizes for effective cell confinement. Fleck, C.A. Rosiak, J.; Rucinska-Rybus, A.; Pekala, W. Method of Manufacturing Hydrogel Dressings. ; Pollard, S.; Tan, Y.; Rodriguez, J.; Visconti, R.P. Hydrogel polymers selected for ocular delivery should be biocompatible, biodegradable, and non-cytotoxic with prolonged retention time. ; Kumar, A.; Kumria, R. Novel approaches in formulation and drug delivery using contact lenses. ; Mahler, S. Monoclonal antibody-targeted polymeric nanoparticles for cancer therapyâFuture prospects. Biomedical applications of hydrogels: A review of patents and commercial products. Yadollahi, M.; Gholamali, I.; Namazi, H.; Aghazadeh, M. Synthesis and characterization of antibacterial carboxymethyl cellulose/ZnO nanocomposite hydrogels. Hydrogel Bioink Reinforcement for Additive Manufacturing: A Focused Review of Emerging Strategies. Mastropietro, D.J. Elzoghby, A.O. From Wichterleâs pioneering work to the most recent hydrogel-based inventions and products on the market, it provides the reader with a detailed introduction to the topic and perspective on further potential developments. ; Cruciani, F.; Vitali, B.; Luppi, B. Chitosan/alginate complexes for vaginal delivery of chlorhexidine digluconate. Data demonstrated that PLGAâsilk fibroinâcollagen scaffolds, particularly the one that contains 50% PLGA, 25% silk fibroin, and 25% collagen, is more suitable for nerve tissue engineering compared to PLGA nanofibrous scaffolds [, Results from cell regeneration and neurofilament protein expression analysis data indicated that the biocomposite nanofibrous, electrospun fabricated scaffold composed of poly(, The main limitations that restrict the extensive use of hydrogels in tissue engineering are uncontrollable swelling, toxic cross-linking processes, inadequate pseudoplastic rheological behavior, and lack of self-healing properties. Therapeutic applications of hydrogels in oral drug delivery. ; Choonara, Y.E. A comprehensive overview on the synthesis of hydrogels by physical cross-linking and chemical cross-linking techniques, materials, procedures, advantages, and disadvantages are depicted in, Due to their ability to undergo large phase transitions triggered by temperature, thermoresponsive hydrogels can incorporate drugs that can be slowly released from the interior of the gel. The fibres that comprise cellulose can be ⦠Topical buparvaquone nano-enabled hydrogels for cutaneous leishmaniasis. Fiorica, C.; Pitarresi, G.; Palumbo, F.S. A self-healing cellulose nanocomposite hydrogel prepared from acylhydrazineterminated polyethylene glycol (PEG) cross-linked with dialdehyde cellulose nanocrystals showed significant increase in the mechanical strength, self-healing efficiency, and biocompatibility of the hydrogel [, Injectable hydrogels are distinguished by inherent fluidly and therefore can be administered through an injection. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Biomedical applications of hydrogels: A review of patents and commercial products. Cyclodextrin complexes: Perspective from drug delivery and formulation. ; Jin, S.; Shin, J.; Song, Y.; Chang Kim, S.; Cho, B.-K.; Lee, J.-K.; et al. Historically, dressings were made of a piece of material, usually a cloth, but the use of cobwebs, dung, leaves and honey have also been described.. ; Woolfson, A.D. Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery. ; Lee, S.-H. Depending on the magnitude of the electric field, they may swell, deswell, or erode and provide pulsatile drug release. ; Murthy, S.N. Yamamoto, T.; Inoue, K.; Tezuka, Y. Hydrogel formation by the âtopological conversionâ of cyclic PLAâPEO block copolymers. ; Nair, A.B. Varaprasad, K.; Jayaramudu, T.; Kanikireddy, V.; Toro, C.; Sadiku, E.R. ; Tsai, T.H. ; Peppas, N.A. ; Whitehead, K.A. We use cookies to help provide and enhance our service and tailor content and ads. Natural hydrogels for cartilage regeneration: Modification, preparation and application. J. Biomed. Barker, K.; Rastogi, S.K. The tensile strength needed from a drug-loaded hydrogel is usually based on the particular site and utilization of the hydrogel in high-stress locations such as cartilage tissue. Formulation and Evaluation of Chitosan-Based Buccal Bioadhesive Films of Zolmitriptan. Even with many promising advances, current technologies are limited in their capacity to regenerate cartilage bearing complex mechanical properties and biochemical composition. Alvarez-Lorenzo, C.; Yañez, F.; Barreiro-Iglesias, R.; Concheiro, A. Imprinted soft contact lenses as norfloxacin delivery systems. ; Kashaf, S.S.; Alvarez, M.M. A synthetic temperature-sensitive graft copolymer based on, This class of hydrogels exhibits pH-dependent swelling because of the changes in the hydrophobic/hydrophilic characteristics of the polymer chain and non-covalent interactions. Sani, E.S. Amirian, J.; Zeng, Y.; Shekh, M.I. For deeper wounds, use an alginate alternative dressing. ; Thalib, B.; Ruslin, M.; Tung, T.D.X. ; Dhert, W.J. Xu, J.; Strandman, S.; Zhu, J.X. Light controlled protein release from a supramolecular hydrogel. ; Shah, J.; Jacob, S.; Saraiya, V.; Attimarad, M.; SreeHarsha, N.; Akrawi, S.H. The extent of swelling is influenced by pH, dissociation constant, and degree of dissociation of charged groups, polymer level, and pH of the external medium. ; Jacob, S. Gellan Gum-Based Hydrogel for the Transdermal Delivery of Nebivolol: Optimization and Evaluation. ; Onuki, Y.; Morishita, M.; Takayama, K. Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery. Hydrogels. Vitaliy V. Khutoryanskiy is Professor of Formulation Science (since August 2014), having previously been Associate Professor (Reader) in Pharmaceutical Materials (2010â2014) and Lecturer in Pharmaceutics (2005â2010) at Reading School of Pharmacy, University of Reading (United Kingdom). Kwarta, C.P. ; Kole, P.L. Jeon, M.S. Eljarrat-Binstock, E.; Domb, A.J. ; Shehata, T.M. GaÄanin, J.; Synatschke, C.V.; Weil, T. Biomedical Applications of DNA-Based Hydrogels. Biomater. Composite hydrogels made of gelatin-grafted dopamine/chitosan/carbon nanotubes [, Irregularly shaped amorphous hydrogel dressings are primarily formulated to rehydrate or to create a favorable moist condition that supports healing of wounds, burns, and tissue damages caused by radiation. ; Lakdawala, D.H.; Shaikh, A.A.; Desai, A.R. Kamoun, E.A. ; McAlister, E.; McCarthy, H.O. The regeneration of cartilage is investigated through a combination of chondrocytes or stem cells, stimulatory growth factors, and bioreactors enclosed within scaffolds preferably made from hydrogels. Lin, J.; Zheng, S.Y. ; Chen, K.T. Please let us know what you think of our products and services. Novel vaginal drug delivery system: Deformable propylene glycol liposomes-in-hydrogel. Lo, C.-W.; Zhu, D.; Jiang, H. An infrared-light responsive graphene-oxide incorporated poly(. ; Salema-Oom, M.; Alvarez-Lorenzo, C.; Serro, A.P. Cheng, Y.H. Dos Santos, A.M.; Carvalho, S.G.; Araujo, V.H.S. The risk for an infection is usually less than 10%. ; Min, B.H. Soft contact lenses capable of sustained delivery of timolol. In order to avoid the problems using single-phase biomaterials, composite scaffolds comprising a number of biomaterials can be utilized. Other examples of wounds that heal by secondary intention are dehisced surgical wounds and pressure ulcers/injuries. Characterization of printable cellular micro-fluidic channels for tissue engineering. Physical adsorption exists between the nanoparticles, and molecular networks with high surface areas associated with nanoparticles can enhance the mechanical strength of these nanocomposite or hybrid hydrogels [, Presently, research is also progressing in the field of nanocomposite hydrogels, including functionalized nanomaterials [, As a robust nanomaterial having excellent biocompatibility, biodegradability, and high mechanical strength, nanoscaled cellulose has possible applications in the areas of pharmaceutical technology and bioengineering. ; Gorkin, R., 3rd; in het Panhuis, M.; Spinks, G.M. ; Walker, J.L. Human hair is considered a waste material in most parts of the world and its accumulation in waste streams causes many environmental problems; however, it has many known uses. We would like to show you a description here but the site wonât allow us. Kim, S.J. Lin, Y.; Sun, J.; Jiang, G.; Zan, J.; Ding, F. In vitro Evaluation of Lysozyme-loaded Microspheres in Thermosensitive Methylcellulose-based Hydrogel1 1Supported by the National Natural Science Foundation of China (No.20576057) and Fundamental Research Foundation of Tsinghua University (JCqn2005033). certain disease conditions such as chronic wounds and tumors; this property can therefore be utilized for targeted drug delivery to cellular compartment or particular tissues [23]. Hydrogel nanoparticles are one of the most promising nanoparticulate drug delivery systems owing to their unique nature combining the features and characteristics of a hydrogel system with a nanoparticle. In addition, the deformation of the imprinted hydrogel utilized for the contact lenses materials may affect the release profile of drugs. Kaul, G.; Amiji, M. Long-circulating poly(ethylene glycol)-modified gelatin nanoparticles for intracellular delivery. ; Howel, C.A. GarcÃa, M.C. In order to impart adequate mechanical strength to hydrogels besides biodegradability, various types of physical and chemical cross-linking methods are currently being employed. It was reported that drugs with oppositely charged interpolyelectrolyte complexes acted as drug reservoirs and exhibited sustained drug release rates in an aqueous medium followed by increased drug release in physiological pH, enhanced by ionic exchange [, The inflammatory process is mediated by B and T lymphocytes but is sustained, amplified, and mediated by polymorphonuclear leukocytes and macrophages. Copyright © 2014 The Authors. Liu, W.; Lee, B.S. ; Yoon, S.G.; Lee, Y.H. Liu, L.; Yao, W.; Rao, Y.; Lu, X.; Gao, J. pH-Responsive carriers for oral drug delivery: Challenges and opportunities of current platforms. ; Swieszkowski, W.; Kurzydlowski, K.J. ; Sharma, G.; Stadler, F.J.; Song, J.; Du, B.; Zhu, Y. In-situ crosslinked hydrogel based on amidated pectin/oxidized chitosan as potential wound dressing for skin repairing. ; Ramakrishna, S. Electrospun bio-composite P(LLA-CL)/collagen I/collagen III scaffolds for nerve tissue engineering. ; Basnet, P.; Tostrup, M.J.; Moueffaq, S.; Å kalko-Basnet, N. Localized Therapy of Vaginal Infections and Inflammation: Liposomes-In-Hydrogel Delivery System for Polyphenols. Kang Derwent, J.J.; Mieler, W.F. Unlike temperature changes, variation in pH exists in the different regions of the body and in certain disease conditions such as chronic wounds and tumors; this property can therefore be utilized for targeted drug delivery to cellular compartment or particular tissues [, Amphiphilic pH-sensitive hydrogels prepared in different molar ratios of hydrophilic poly(methacrylic acidâgraftedâethylene glycol) conjugated with hydrophobic poly (methyl methacrylate) (PMMA) nanoparticles have been reported [, Smart hydrogels such as dual sensitive pentablock copolymers were synthesized through chemical conjugation between thermosensitive segment, poly(ε-caprolactone)-, Photoresponsive hydrogels generally consist of a photoreactive chromophore as the functional part of the polymer chain. [. Laffleur, F.; Egeling, M. Evaluation of cellulose based patches for oral mucosal impairment. The data presented in this study is contained within this article. Laffleur, F. Mucoadhesive polymers for buccal drug delivery. In vitro and in vivo evaluation of a hydrogel-based prototype transdermal patch system of alfuzosin hydrochloride. In podiatry practitioners such as chiropodists, podiatrists and foot health practitioners remove conditions such as calluses and verrucas. An attempt has been made to circumvent these issues by modifying collagen hydrogel using 8-arm polyethylene glycol-maleimide cross-linker by thiol-Michael addition click reaction [, Alginate-based hydrogels have been extensively evaluated in tissue engineering since they carry several characteristics akin to human extra cellular matrix. Defined as a three-dimensional (3D) hydrophilic polymer capable of ⦠; Shukla, S.K. Jacob, S.; Nair, A.B. Murdan, S. Electro-responsive drug delivery from hydrogels. Synthesis and characterization of grafted thermosensitive hydrogels for heating activated controlled release. Jacob, S.; Nair, A.B. Chimene, D.; Kaunas, R.; Gaharwar, A.K. The drug molecule is either conjugated to the surface of the nanoparticles or encapsulated and protected inside the core. We use cookies on our website to ensure you get the best experience. Anroop, B.N. Author to whom correspondence should be addressed. ; Yang, H. Hydrogel-based ocular drug delivery systems: Emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations. This review provides an analysis of their main characteristics and biomedical applications. A thermoresponsive PLGA-PEG-PLGA hydrogel was demonstrated to prolong the delivery of Avastin, Intracameral delivery of drugs permits drug diffusion into anterior chamber and a few posterior ocular tissues. Gelatin-based nanoparticles as drug and gene delivery systems: Reviewing three decades of research. Poldervaart, M.T. For instance, Pluronic, An improved mucoadhesion was observed in a hydrogel combination made of HPMC (5%, A novel delivery system prepared from post-expansile hydrogel foam aerosol of propylene glycol-liposomes constituting matrices for vaginal drug delivery applications has been reported. Hydrogels have become very popular due to their unique properties such as high water content, softness, flexibility and biocompatibility. Polyelectrolyte nanogels can act as pharmaceutical carriers by accommodating oppositely charged low-molecular-weight drugs and macromolecules such as oligo- and polynucleotides (siRNA, DNA) as well as proteins as targeting motifs. ; Jeong, B. Biodegradable thermogels. Examples are UrgoClean (Urgo Medical) (Figure 2) and monofilament debridement pads (National Institute for Health and ; Rolland, J.P.; Napier, M.E. In. Sharifzadeh, G.; Hosseinkhani, H. Biomolecule-Responsive Hydrogels in Medicine. Bakarich, S.E. Molecularly imprinted materials capable of specific recognition of the template in aqueous environments with minimum nonspecific interactions with drugs and other excipients are the main focus of current investigations in this field. In comparison to synthetic polymers, natural polymers are more biodegradable and bioactive, besides improving cell adhesion, proliferation, and growth. Li, J.; Mooney, D.J. ; Park, J.Y. From the ancient Romans, through the Middle Ages, to the late of the nineteenth century, the Aristotelian doctrine of spontaneous generation was one of the most basic laws. Jacob, S.; Nair, A.B. Um, S.H. Stimuli-responsive polymers and their applications in drug delivery. ; Aghaloo, T.; Lee, M. Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering. Jiang, T.; Wang, T.; Li, T.; Ma, Y.; Shen, S.; He, B.; Mo, R. Enhanced Transdermal Drug Delivery by Transfersome-Embedded Oligopeptide Hydrogel for Topical Chemotherapy of Melanoma. Maximal drug loading is restricted by the template molecules and functional monomers of the imprinted hydrogel. Xiao, G.; Wang, Y.; Zhang, H.; Chen, L.; Fu, S. Facile strategy to construct a self-healing and biocompatible cellulose nanocomposite hydrogel via reversible acylhydrazone. ; Rao, B.S. Jøraholmen, M.W. Overview of therapeutic ultrasound applications and safety considerations. Thermosensitive and mucoadhesive pluronic-hydroxypropylmethylcellulose hydrogel containing the mini-CD4 M48U1 is a promising efficient barrier against HIV diffusion through macaque cervicovaginal mucus. ; Wang, J.J.; Chu, C.C. ... HYDROGELS. Bouchemal, K.; Aka-Any-Grah, A.; Dereuddre-Bosquet, N.; Martin, L.; Lievin-Le-Moal, V.; Le Grand, R.; Nicolas, V.; Gibellini, D.; Lembo, D.; Poüs, C.; et al. Examples of hybrid and composite hydrogels based on HAMA. Lee, S.B. Hydrogels in ophthalmic applications. Furthermore, pulsatile or bolus delivery can be electrically modulated and the method requires only minimally invasive patient monitoring [, Due to high water content, swollen hydrogels can provide ease of application and more comfort for patients compared to transdermal patches. 3D Printing Technologies: Recent Development and Emerging Applications in Various Drug Delivery Systems. ; Aldawood, Z.; Bassir, S.H. Xu, X.; Zeng, Z.; Huang, Z.; Sun, Y.; Huang, Y.; Chen, J.; Ye, J.; Yang, H.; Yang, C.; Zhao, C. Near-infrared light-triggered degradable hyaluronic acid hydrogel for on-demand drug release and combined chemo-photodynamic therapy. Brown, T.D. Sharpe, L.A.; Daily, A.M.; Horava, S.D. Kumria, R.; Nair, A.B. Ho, D.K. Received: 3 February 2021 / Revised: 27 February 2021 / Accepted: 4 March 2021 / Published: 8 March 2021, (This article belongs to the Special Issue. ; Choksi, H.H. Ocular bioavailability and duration of action was found to be more compared to ophthalmic drops, pilocarpine injection, or drug-loaded PNIPAAm [, Biodegradable PLGA microspheres containing the anti-vascular endothelial growth factor aflibercept for ocular drug delivery have been disclosed [, Due to beneficial physicomechanical properties such as wound leakage (>80 mmHg), duration of cross-linking (<30 s), bioadhesive strength (0.1 kPa), mechanical strength (5â200 kPa), percentage swelling (<200%, Various hydrogel polymers are being evaluated to find an alternative for vitreous substitutes including HPMC, hyaluronic acid/gellan gum, pHEMA, poly (glycerol methacrylate), siloxanes, PVA, and PVP [, Contact lenses provide a safe and effective way to correct vision, when used with personal care and proper supervision.
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